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Published March 27, 2000 | Published
Journal Article Open

An optical coherence microscope for 3-dimensional imaging in developmental biology

Abstract

An optical coherence microscope (OCM) has been designed and constructed to acquire 3-dimensional images of highly scattering biological tissue. Volume-rendering software is used to enhance 3-D visualization of the data sets. Lateral resolution of the OCM is 5 mm (FWHM), and the depth resolution is 10 mm (FWHM) in tissue. The design trade-offs for a 3-D OCM are discussed, and the fundamental photon noise limitation is measured and compared with theory. A rotating 3-D image of a frog embryo is presented to illustrate the capabilities of the instrument.

Additional Information

©2000 Optical Society of America. Received February 02, 2000; Revised March 20, 2000. Support for this work has been provided by a Special Opportunity Award from the Whitaker Foundation to Harvey Mudd College and by a National Science Foundation Grant DBI-9612240.

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August 21, 2023
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