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Published July 1, 1961 | public
Journal Article Open

The effects of pressure on the buoyant behavior of deoxyribonucleic acid and tobacco mosaic virus in a density gradient at equilibrium in the ultracentrifuge

Abstract

In the original analysis(1) of the behavior of macromolecules and viruses in a buoyant density gradient at equilibrium in the ultracentrifuge, all components were assumed to be incompressible. As a few hundred atmospheres are normally generated in the liquid, it is to be expected that previous results based on the assumption of incompressibility require re-examination.

Additional Information

© 1961 by the National Academy of Sciences. Communicated by Linus Pauling, May 29, 1961. This investigation was supported in part by Research Grant H-3394 from the National Institutes of Health, U.S. Public Health Service. [J.E.H. was a] Predoctoral Fellow of the National Science Foundation. [J.B.I. was a] U.S. Public Health Service Research Fellow of the Division of General Medical Sciences. Gates and Crellin Laboratories of Chemistry, Contribtion No. 2701.

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Created:
August 21, 2023
Modified:
October 16, 2023