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Published May 28, 2008 | Published + Supplemental Material
Journal Article Open

Dissociating the Role of the Orbitofrontal Cortex and the Striatum in the Computation of Goal Values and Prediction Errors

Abstract

To make sound economic decisions, the brain needs to compute several different value-related signals. These include goal values that measure the predicted reward that results from the outcome generated by each of the actions under consideration, decision values that measure the net value of taking the different actions, and prediction errors that measure deviations from individuals' previous reward expectations. We used functional magnetic resonance imaging and a novel decision-making paradigm to dissociate the neural basis of these three computations. Our results show that they are supported by different neural substrates: goal values are correlated with activity in the medial orbitofrontal cortex, decision values are correlated with activity in the central orbitofrontal cortex, and prediction errors are correlated with activity in the ventral striatum.

Additional Information

© 2008 Society for Neuroscience. Received January 8, 2008; accepted April 21, 2008. This work was supported by the Moore Foundation.

Attached Files

Published - HARjns08.pdf

Supplemental Material - HARjns08suplegend.pdf

Supplemental Material - HARjns08suppFig1.gif

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