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Published December 17, 2008 | Accepted Version
Journal Article Open

DNA-Mediated Electrochemistry

Abstract

The base pair stack of DNA has been demonstrated as a medium for long-range charge transport chemistry both in solution and at DNA-modified surfaces. This chemistry is exquisitely sensitive to structural perturbations in the base pair stack as occur with lesions, single base mismatches, and protein binding. We have exploited this sensitivity for the development of reliable electrochemical assays based on DNA charge transport at self-assembled DNA monolayers. Here, we discuss the characteristic features, applications, and advantages of DNA-mediated electrochemistry.

Additional Information

Copyright © 2008 American Chemical Society. Received July 22, 2008; Revised Manuscript Received September 2, 2008. Publication Date (Web): November 4, 2008. We gratefully acknowledge the NIH (GM61077) for their financial support. We are also very grateful to our many co-workers who have helped in elucidating this chemistry. We thank in particular Prof. M.G. Hill, without whom this chemistry could not have been discovered and described.

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