Published October 2005
| Published
Journal Article
Open
Tradeoff between short-term and long-term adaptation in a changing environment
- Creators
- Forster, Robert
- Wilke, Claus O.
Abstract
We investigate the competition dynamics of two microbial or viral strains that live in an environment that switches periodically between two states. One of the strains is adapted to the long-term environment, but pays a short-term cost, while the other is adapted to the short-term environment and pays a cost in the long term. We explore the tradeoff between these alternative strategies in extensive numerical simulations and present a simple analytic model that can predict the outcome of these competitions as a function of the mutation rate and the time scale of the environmental changes. Our model is relevant for arboviruses, which alternate between different host species on a regular basis.
Additional Information
© 2005 The American Physical Society (Received 16 December 2004; revised 15 July 2005; published 20 October 2005) This work was supported by NIH Grant NO. AI 065960.Attached Files
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Additional details
- Eprint ID
- 1336
- Resolver ID
- CaltechAUTHORS:FORpre05
- AI 065960
- NIH
- Created
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2006-01-11Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field