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Published June 1967 | Published
Journal Article Open

Morphology of deoxyribonucleic acid extracted from cores of vaccinia virus

Abstract

It has been shown recently that the outer layers of vaccinia virions can be removed selectively under mild conditions to yield a preparation that consists entirely of "cores" (K. B. Easterbrook, Ultrastruct. Res. 14:484, 1966). Since these cores can be very easily ruptured and dissolved, they would seem to offer advantages over complete virions as starting material for the extraction of unbroken genomes. This note describes results obtained in an investigation into the morphology of DNA isolated from vaccinia viral cores by further detergent treatment.

Additional Information

© 1967 American Society for Microbiology. Received for publication 25 March 1967. The technical assistance of Margaret Freeman, who made the measurements, is gratefully acknowledged. This investigation was supported by Public Health Service International Postdoctoral Fellowship 1 F05-TW-980-01 and by Public Health Service grant 5 ROI A104229-5(VR) from the National Institute of Allergy and Infectious Diseases.

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Created:
August 21, 2023
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October 16, 2023