Published September 1986
| public
Journal Article
Interactions of synthetic polymers with cell membranes and model membrane systems. 11. Glucose-dependent disruption of phospholipid vesicle membranes
- Creators
- Devlin, Brian P.
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Tirrell, David A.
Abstract
Poly(α-ethylacrylic acid) (PEAA, 1) undergoes a conformational transition to a globular structure upon acidification of its aqueous solutions. The globular polymer [1] associates strongly with bilayer vesicles prepared from phosphatidylcholines and phosphatidylglycerols, with profound disruption of bilayer organization. The latter phenomenon allows the formulation of phospholipid vesicles that release their contents rapidly and quantitatively in response to small changes in environmental pH. We show herein that this process can be combined with enzymic generation of H^+ to produce vesicles sensitive to low concentrations of neutral organic solutes such as glucose.
Additional Information
© 1986 American Chemical Society. Received June 10, 1986. This work was supported by a grant from the 3M Co. and by a Presidential Young Investigator Award of the National Science Foundation (to D.A.T.). Part 11 in the series "Interactions of Synthetic Polymers with Cell Membranes and Model Membrane Systems". For Part 10, see: Ramaswami, V.; Tirrell, D. A. J. Polym. Sci., Polym. Chem. Ed. 1986, 24, 241.Additional details
- Eprint ID
- 53598
- DOI
- 10.1021/ma00163a028
- Resolver ID
- CaltechAUTHORS:DEVm1986
- 3M
- NSF
- Created
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2015-01-22Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field