Published December 23, 2008
| Published
Journal Article
Open
Properties of developmental gene regulatory networks
- Creators
- Davidson, Eric H.
- Levine, Michael S.
Abstract
The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits controlling the specification of the mesectoderm in the Drosophila embryo and the endomesoderm in the sea urchin, even though the respective subcircuits are composed of nonorthologous regulatory genes.
Additional Information
© 2008 by The National Academy of Sciences of the USA. Edited by Gertrud M. Schüpbach, Princeton University, Princeton, NJ, and approved September 11, 2008 (received for review July 24, 2008). This article is a PNAS Direct Submission. Published online before print December 22, 2008, doi: 10.1073/pnas.0806007105 We thank Susan Marty for superb administrative assistance and David Stopak for his editorial oversight. This work was supported by the National Academy of Sciences Sackler Colloquium program and National Institutes of Health Grants HD37105 (to E.H.D.) and GM34431 (to M.L.). Sackler Special Feature: Introductory Perspective [from the cover]. This paper results from the Arthur M. Sackler Colloquium of the National Academy of Sciences, "Gene Networks in Animal Development and Evolution," held February 15–16, 2008, at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering in Irvine, CA. The complete program and audio files of most presentations are available on the NAS web site at http://www.nasonline.org/SACKLER_Gene_Networks. Author contributions: E.H.D. and M.L. wrote the paper. The authors declare no conflict of interest.Attached Files
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Additional details
- PMCID
- PMC2629280
- Eprint ID
- 13014
- Resolver ID
- CaltechAUTHORS:DAVpnas08
- National Academy of Sciences
- HD37105
- NIH
- GM34431
- NIH
- Created
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2009-01-15Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field