Published December 1988
| Published
Journal Article
Open
Free boundary problems in controlled release pharmaceuticals: II. swelling-controlled release
- Creators
- Cohen, Donald S.
- Erneux, Thomas
Abstract
A problem in controlled release pharmaceutical systems is formulated and studied. The device modeled is a polymer matrix containing an initially immobilized drug. The release of the drug is achieved by countercurrent diffusion through a penetrant solvent with the release rate being determined by the rate of diffusion of the solvent in the polymer. The mathematical theory yields a free boundary problem which is studied in various asymptotic regimes.
Additional Information
©1988 Society for Industrial and Applied Mathematics. Received by the editors September 10, 1986; accepted for publication (in revised form) September 16, 1987. [D.S.C] was supported in part by U.S. Army Research Office (Durham) under contract DAAG29-85-K-0092, by the National Science Foundation under grant DMS-8706642, and by the Department of Energy under grant 7405/ENG-36 at the Center for Nonlinear Studies at Los Alamos. [T.E] was supported in part by the Air Force Office of Scientific Research under grant AFOSR85-0150 and the National Science Foundation under grant DMS-8701302.Attached Files
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Additional details
- Eprint ID
- 12669
- Resolver ID
- CaltechAUTHORS:COHsiamjam88b
- DAAG29-85-K-0092
- Army Research Office
- DMS-8706642
- National Science Foundation
- 7405/ENG-36
- Department of Energy
- AFOSR85-0150
- Air Force Office of Scientific Research
- DMS-8701302
- National Science Foundation
- Created
-
2008-12-24Created from EPrint's datestamp field
- Updated
-
2021-11-08Created from EPrint's last_modified field
- Caltech groups
- GALCIT