Simultaneous in vivo positron emission tomography and magnetic resonance imaging
Abstract
Positron emission tomography (PET) and magnetic resonance imaging (MRI) are widely used in vivo imaging technologies with both clinical and biomedical research applications. The strengths of MRI include high-resolution, high-contrast morphologic imaging of soft tissues; the ability to image physiologic parameters such as diffusion and changes in oxygenation level resulting from neuronal stimulation; and the measurement of metabolites using chemical shift imaging. PET images the distribution of biologically targeted radiotracers with high sensitivity, but images generally lack anatomic context and are of lower spatial resolution. Integration of these technologies permits the acquisition of temporally correlated data showing the distribution of PET radiotracers and MRI contrast agents or MR-detectable metabolites, with registration to the underlying anatomy. An MRI-compatible PET scanner has been built for biomedical research applications that allows data from both modalities to be acquired simultaneously. Experiments demonstrate no effect of the MRI system on the spatial resolution of the PET system and <10% reduction in the fraction of radioactive decay events detected by the PET scanner inside the MRI. The signal-to-noise ratio and uniformity of the MR images, with the exception of one particular pulse sequence, were little affected by the presence of the PET scanner. In vivo simultaneous PET and MRI studies were performed in mice. Proof-of-principle in vivo MR spectroscopy and functional MRI experiments were also demonstrated with the combined scanner.
Additional Information
Copyright © 2008 by the National Academy of Sciences. Freely available online through the PNAS open access option. Communicated by Michael E. Phelps, University of California School of Medicine, Los Angeles, CA, December 11, 2007 (received for review May 15, 2007) We thank Kanai Shah and Richard Farrell of Radiation Monitoring Devices, Inc. (Watertown, MA) for supplying PSAPDs and for their expert advice; Drs. Yongfeng Yang and Jeff Walton for many useful discussions; Andrey Demyanenko for constructing the RF coils used in the in vivo imaging studies; and Dr. Andrew Raubitschek of the City of Hope Medical Center (Duarte, CA) for the MC38 tumor-bearing mouse. We gratefully acknowledge the support of the Gordon and Betty Moore Foundation to the Caltech Brain Imaging Center. This work was supported by National Institutes of Health (NIH) Grant R01 EB00993; National Center for Research Resources Grant U24 RR021760 ("Mouse BIRN"); Department of Energy Small Business Innovation Research (SBIR) Grant DE-FG02-06ER84432; NIH SBIR Grant R43 NS055377; and NIH Grant R01 EB00194 (to J.Q.). Author contributions: C.C., D.P., Y.W., M.S.J., B.J.P., R.E.J., and S.R.C. designed research; C.C., D.P., and Y.W. performed research; J.Q. contributed new reagents/analytic tools; C.C., D.P., Y.W., M.S.J., J.Q., B.J.P., R.E.J., and S.R.C. analyzed data; and C.C. wrote the paper. The authors declare no conflict of interest. This article contains supporting information online at www.pnas.org/cgi/content/full/0711622105/DC1.Attached Files
Published - CATpnas08.pdf
Supplemental Material - CATpnas08fig5.pdf
Supplemental Material - CATpnas08fig6.pdf
Supplemental Material - CATpnas08fig7.pdf
Supplemental Material - CATpnas08tab1-2.pdf
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Additional details
- PMCID
- PMC2268792
- Eprint ID
- 9703
- Resolver ID
- CaltechAUTHORS:CATpnas08
- Gordon and Betty Moore Foundation
- R01 EB00993
- NIH
- U24 RR021760
- National Center for Research Resources (NCRR)
- DE-FG02-06ER84432
- Department of Energy (DOE)
- R43 NS055377
- NIH
- R01 EB00194
- NIH
- Created
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2008-03-13Created from EPrint's datestamp field
- Updated
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2023-06-01Created from EPrint's last_modified field