The effect of isoelectric amino acids on the pH(+) of a phosphate buffer solution - A contribution in support of the "Zwitter Ion" hypothesis
- Creators
- Borsook, Henry
- MacFadyen, Douglas A.
Abstract
The relative merits of the classical conception and of the Zwitter Ion conception of the dissociation of amphoteric electrolytes are discussed, and the following data are presented which confirm the Zwitter Ion hypothesis of Bjerrum, and which are not in accord with the classical view. 1. Amino acids in the isoelectric form resemble strong electrolytes in that they contribute to the ionic strength of the solution. 2. The dielectric constants of aqueous solutions of amino acids, like those of solutions of strong electrolytes greater than 0.02 normal, are considerably greater than that of pure water. 3. The magnitude of the dissociation constants of substituted acetic acids and of glycine, are more easily accounted for with the Zwitter Ion than with the classical conception.
Additional Information
© 1930 Rockefeller University Press. RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Accepted for publication, February 1, 1930. The authors wish to thank Professor Hardolph Wasteneys, of the University of Toronto, Professor Linus Pauling, and Professor Fritz Zwicky, of the California Institute of Technology, for assistance in and criticism of this work.Attached Files
Published - BORjgp30b.pdf
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Additional details
- PMCID
- PMC2141070
- Eprint ID
- 11828
- Resolver ID
- CaltechAUTHORS:BORjgp30b
- Created
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2008-10-08Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field