Methionine formation by transmethylation in vitro

Abstract

We reported in a previous communication (1) that guanidoacetic acid is methylated to creatine by rat liver slices in the presence of choline and either homocysteine or homocystine. Choline, homocystine, or homocysteine alone had little or no effect. These observations closed the gap which had existed between the evidence from tissue slice experiments on the one hand (2) and that from experiments in viva on the other (3-5) regarding the transfer of choline methyl in the formation of creatine.

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