Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published November 1996 | Published
Journal Article Open

Fc receptors and their interactions with immunoglobulins

Abstract

Receptors for the Fc domain of immunoglobulins play an important role in immune defense. There are two well-defined functional classes of mammalian receptors. One class of receptors transports immunoglobulins across epithelial tissues to their main sites of action. This class includes the neonatal Fc receptor (FcRn), which transports immunoglobulin G (IgG), and the polymeric immunoglobulin receptor (pIgR), which transports immunoglobulin A (IgA) and immunoglobulin M (IgM). Another class of receptors present on the surfaces of effector cells triggers various biological responses upon binding antibody-antigen complexes. Of these, the IgG receptors (FcγR) and immunoglobulin E (IgE) receptors (FcεR) are the best characterized. The biological responses elicited include antibody-dependent, cell-mediated cytotoxicity, phagocytosis, release of inflammatory mediators, and regulation of lymphocyte proliferation and differentiation. We summarize the current knowledge of the structures and functions of FcRn, pIgR, and the FcγR and FcεRI proteins, concentrating on the interactions of the extracellular portions of these receptors with immunoglobulins.

Additional Information

"Reprinted, with permission, from the Annual Review of Cell and Developmental Biology, Volume 12 copyright 1996 by Annual Reviews, www.annualreviews.org" We thank Dan Vaughn and Bob Turring for help with figures, Neil Simister and Sally Ward for communicating results prior to publication and for helpful discussions, Sherie Morrison and Dan Vaughn for helpful discussions, and Dan Vaughn and Luis Sanchez for critical reading of the manuscript. MR was supported by a fellowship from the Cancer Research Institute. PJB is supported by the Howard Hughes Medical Institute and a Camille and Henry Dreyfuss Teacher Scholar Award. Ribbon diagrams were prepared using MOLSCRIPT (Kraulis 1991).

Attached Files

Published - BJOarcdb96.pdf

Files

BJOarcdb96.pdf
Files (938.4 kB)
Name Size Download all
md5:f75de209e1cbc234a2e14ef5aced0f46
938.4 kB Preview Download

Additional details

Created:
August 22, 2023
Modified:
October 13, 2023