A Membrane-Associated RNA of Cytoplasmic Origin in Hela Cells
- Creators
- Attardi, Barbara
- Attardi, Giuseppe
Abstract
The genetic evidence of the existence in yeast [1] and molds [2] of cytoplasmic determinants controlling the structure and function of mitochondria and the demonstration that mitochondria from all organisms contain DNA [3-7] have indicated that transcription and translation processes dependent on cytoplasmic genes occur in eukaryotic cells. More recent observations in Neurospora have suggested that a cytoplasmic, presumably mitochondrial, genetic determinant controls the structural proteins of different membrane systems (mitochondria, microsomes, nuclear membrane) [8, 9]; these structural proteins, from their amino acid composition, fingerprinting pattern, and immunological behavior, appear to be identical or to have a common component. [8, 9] These findings suggest that cytoplasmic genes may have a wider role in the cell than hitherto suspected and may direct a considerable fraction of mRNA and protein synthesis.
Additional Information
Copyright © 1967 by National Academy of Sciences Communicated by Renato Dulbecco, June 23, 1967. This work was supported by a research grant from the U.S. Public Health Service (GM-11726). One of us (B. A.) was supported by a National Defense and Education Act Fellowship. The excellent assistance of Mrs. LaVerne Wenzel and Mrs. Benneta Keeley is gratefully acknowledged.Files
Name | Size | Download all |
---|---|---|
md5:ff6209c9f53915c2902b867cd076e7da
|
1.1 MB | Preview Download |
Additional details
- Eprint ID
- 708
- Resolver ID
- CaltechAUTHORS:ATTpnas67
- Created
-
2005-09-15Created from EPrint's datestamp field
- Updated
-
2019-10-02Created from EPrint's last_modified field