Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published September 2004 | Published
Book Section - Chapter Open

Recording advances for neural prosthetics

Abstract

An important challenge for neural prosthetics research is to record from populations of neurons over long periods of time, ideally for the lifetime of the patient. Two new advances toward this goal are described, the use of local field potentials (LFPs) and autonomously positioned recording electrodes. LFPs are the composite extracellular potential field from several hundreds of neurons around the electrode tip. LFP recordings can be maintained for longer periods of time than single cell recordings. We find that similar information can be decoded from LFP and spike recordings, with better performance for state decodes with LFPs and, depending on the area, equivalent or slightly less than equivalent performance for signaling the direction of planned movements. Movable electrodes in microdrives can be adjusted in the tissue to optimize recordings, but their movements must be automated to be a practical benefit to patients. We have developed automation algorithms and a meso-scale autonomous electrode testbed, and demonstrated that this system can autonomously isolate and maintain the recorded signal quality of single cells in the cortex of awake, behaving monkeys. These two advances show promise for developing very long term recording for neural prosthetic applications.

Additional Information

© 2004 IEEE. Reprinted with permission. We thank Tessa Yao for administrative support, Betty Grieve, Kelsie Pejsa, and Lea Martel for technical support, and Viktor Shcherbatyuk for computer support. We wish to acknowledge the support of the Defense Advanced Research Projects Agency, the National Eye Institute, the Office of Naval Research, the Boswell Foundation, the National Science Foundation, the Christopher Reeve Paralysis Foundation, and the Human Frontier Science Program.

Attached Files

Published - ANDembc04.pdf

Files

ANDembc04.pdf
Files (1.0 MB)
Name Size Download all
md5:130d59a20e7e3ef1018ccdfc26c6e74a
1.0 MB Preview Download

Additional details

Created:
August 22, 2023
Modified:
October 17, 2023