Restructuring of amygdala subregion apportion across adolescence
Abstract
Total amygdala volumes develop in association with sex and puberty, and postmortem studies find neuronal numbers increase in a nuclei specific fashion across development. Thus, amygdala subregions and composition may evolve with age. Our goal was to examine if amygdala subregion absolute volumes and/or relative proportion varies as a function of age, sex, or puberty in a large sample of typically developing adolescents (N = 408, 43 % female, 10–17 years). Utilizing the in vivo CIT168 atlas, we quantified 9 subregions and implemented Generalized Additive Mixed Models to capture potential non-linear associations with age and pubertal status between sexes. Only males showed significant age associations with the basolateral ventral and paralaminar subdivision (BLVPL), central nucleus (CEN), and amygdala transition area (ATA). Again, only males showed relative differences in the proportion of the BLVPL, CEN, ATA, along with lateral (LA) and amygdalostriatal transition area (ASTA), with age. Using a best-fit modeling approach, age, and not puberty, was found to drive these associations. The results suggest that amygdala subregions show unique variations with age in males across adolescence. Future research is warranted to determine if our findings may contribute to sex differences in mental health that emerge across adolescence.
Additional Information
© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. Received 28 May 2020, Revised 5 November 2020, Accepted 13 November 2020, Available online 11 December 2020. The research above was supported by the following grants, R01 AA017664 (PI: Nagel), R21 MH099618 (PI: Nagel), R03 HD090308 (PI: Herting), K01 MH108761 (PI: Herting), and NIMH P50 MH094258 #8198 (PI: Tyszka). We also thank the families who contributed their time and participated in the above study. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors have no conflict of interests to declare.Attached Files
Published - 1-s2.0-S187892932030133X-main.pdf
Submitted - 690875v2.full.pdf
Supplemental Material - 1-s2.0-S187892932030133X-mmc1.docx
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Additional details
- PMCID
- PMC7820032
- Eprint ID
- 97031
- Resolver ID
- CaltechAUTHORS:20190710-130706254
- R01 AA017664
- NIH
- R21 MH099618
- NIH
- R03 HD090308
- NIH
- K01 MH108761
- NIH
- P50 MH094258
- NIH
- Created
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2019-07-10Created from EPrint's datestamp field
- Updated
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2023-06-01Created from EPrint's last_modified field