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Published June 2012 | Published
Journal Article Open

Incorporating Genomics into the Toolkit of Nematology

Abstract

The study of nematode genomes over the last three decades has relied heavily on the model organism Caenorhabditis elegans, which remains the best-assembled and annotatedmetazoan genome. This is now changing as a rapidly expanding number of nematodes of medical and economic importance have been sequenced in recent years. The advent of sequencing technologies to achieve the equivalent of the $1000 human genome promises that every nematode genome of interest will eventually be sequenced at a reasonable cost. As the sequencing of species spanning the nematode phylumbecomes a routine part of characterizing nematodes, the comparative approach and the increasing use of ecological context will help us to further understand the evolution and functional specializations of any given species by comparing its genome to that of other closely and more distantly related nematodes.We review the current state of nematode genomics and discuss some of the highlights that these genomes have revealed and the trend and benefits of ecological genomics, emphasizing the potential for new genomes and the exciting opportunities this provides for nematological studies.

Additional Information

© 2012 The Society of Nematologists. We would like to thank all the researchers who have contributed to the wealth of literature from which we have drawn and from which we have been stimulated, enlightened, and encouraged. We also wish to thank Ganpati Jagdale and Parwinder Grewal for organizing the "EPNs as model systems in stress physiology and evolutionary biology" symposium at the 2011 Society of Nematologists annual meeting, and for inviting the authors to contribute. We express gratitude to Hillel Schwartz, Jagan Srinivasan, James Baldwin, Mihoko Kato, Margaret Ho, and two reviewers for helpful comments and discussion on the manuscript. ARD was supported by a United States Public Health Service Training Grant (T32GM07616). PWS is an investigator with the Howard Hughes Medical Institute.

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