MicroRNA-125 in Immunity and Cancer
- Creators
- Wang, Jessica K.
- Wang, Zhe
- Li, Guideng
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that play a wide variety of critical roles in different biological processes by post-transcriptionally regulating gene expression. They access diverse regulatory pathways during various stages of cellular differentiation, growth, and apoptosis, and can contribute to both normal and diseased functions. One important family of miRNAs involved in these functions is the miR-125 family (miR-125a and miR-125b). Investigations have been made to increasingly uncover the mechanisms by which the miR-125 family regulates normal homeostasis and growth in a variety of cell types including immune cells, and how dysregulation of miR-125a and miR-125b can lead to disease pathogenesis and tumorigenesis. In this review, we summarize what is currently known about miR-125a and miR-125b, mainly focusing on their roles in immune cell development and function as well as tumor suppression and promotion.
Additional Information
© 2019 Published by Elsevier B.V. Received 19 February 2019, Revised 9 April 2019, Accepted 9 April 2019, Available online 12 April 2019.Additional details
- Eprint ID
- 94714
- Resolver ID
- CaltechAUTHORS:20190415-142956358
- Created
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2019-04-16Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field