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Published December 5, 2014 | public
Journal Article

From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo

Abstract

A central question in contemporary stem and developmental biology and modern medicine is how developmental potential becomes progressively restricted as development proceeds. How totipotency—namely the ability to give rise to both embryonic and extraembryonic tissues and, in an ideal situation to the entire organism—is lost. How do cells choose between alternative fates, and how do they stereotypically organize themselves into developing tissues? Today, one can strip differentiated cells of their identity by inducing pluripotency, but it is still largely unknown how pluripotency emerges in its native context within the early embryo. Indeed, the only true pluripotent cell population—the epiblast—exists in vivo within the early mammalian embryo.

Additional Information

© 2014 The Author(s) Published by the Royal Society. One contribution of 14 to a Theme Issue 'From pluripotency to differentiation: laying the foundations for the body pattern in the mouse embryo'.

Additional details

Created:
August 20, 2023
Modified:
October 20, 2023