Published August 1950
| Published
Journal Article
Open
The sulfonamide-requiring mutant of Neurospora: threonine-methionine antagonism
- Creators
- Zalokar, Marko
Abstract
The present paper reports experiments that partially identify the reaction responsible for the sulfonamide-requiring character. From studies previously reported it has been supposed that there is a gene-controlled deleterious reaction (in sfo strains) that requires relatively higher levels of PABA than are needed for other PABA-dependent metabolic reactions. The present studies show that the deleterious reaction also requires somewhat more methionine (or homocysteine) than the minimum required for normal growth and that the inhibition resulting from excess methionine is competitively antagonized by threonine (or homoserine).
Additional Information
© 1950 American Society for Microbiology. Received for publication April 10, 1950. This investigation was supported by a grant from the American Cancer Society upon the recommendation of the Committee on Growth of the National Research Council. The author is grateful to Dr. Sterling Emerson for reading the manuscript and for helpful suggestions and criticisms.Attached Files
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Additional details
- PMCID
- PMC385862
- Eprint ID
- 93211
- Resolver ID
- CaltechAUTHORS:20190225-094332912
- American Cancer Society
- Created
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2019-02-25Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field