Fluorescence apertureless near-field microscope: a step toward imaging information in DNA
Abstract
Single molecule imaging with optical methods has become an important tool in biophysical studies. However, when imaging molecules at room temperature using far field optics, one can only resolve molecules that are separated by a distance greater than the diffraction limit of the microscope, about 220 nanometers. Near field techniques have allowed researchers to image with resolutions on the order of 30-50 nanometers. However, there are numerous reasons to try to push the resolution limit further. One that particular concerns our group is the \notion to try to image information in DNA in order to measure sequence information. To that end, we have developed a new type of near field microscope, the fluorescence apertureless near field microscope.
Additional Information
© 2000 Society of Photo-Optical Instrumentation Engineers (SPIE).Attached Files
Published - 199.pdf
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Additional details
- Eprint ID
- 91451
- Resolver ID
- CaltechAUTHORS:20181204-132722458
- Created
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2018-12-06Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field
- Series Name
- Proceedings of SPIE
- Series Volume or Issue Number
- 3922