Laser-induced photoacoustic tomography for small animals
- Other:
- Oraevsky, Alexander A.
Abstract
Photoacoustic tomography, also called opto-acoustic tomography when laser excitation is used, is a novel medical imaging modality that combines the merits of both light and ultrasound. Here, we present our study of laser-induced photoacoustic tomography of organs of small animals. Pulses of 6.5 ns in width from an Nd:YAG laser at 532 nm or 1064 nm are employed to generate the distribution of thermoelastic expansion in the sample. A wide-band ultrasonic transducer that is non-focused in the imaging plane scans around the sample to realize a full-view detection of the imaged cross-section. A modified back-projection algorithm is applied to reconstruct the distribution of optical absorption inside the biological sample. Using optical energy depositions that fall below safe levels, tissue structures in ex-vivo rat kidneys and in-situ mouse brains covered by the skin and skull are imaged successfully with the high intrinsic optical contrast and the high spatial resolution of ultrasound.
Additional Information
© 2003 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank G. Ku for experimental assistance. The research was supported in part by DOD, NIH, NSF, and Texas ARP.Attached Files
Published - 40.pdf
Files
Name | Size | Download all |
---|---|---|
md5:e19445b14eee7ae3725eceab60d084b4
|
185.3 kB | Preview Download |
Additional details
- Eprint ID
- 90019
- Resolver ID
- CaltechAUTHORS:20180927-114225816
- Army Medical Research and Materiel Command
- NIH
- NSF
- Texas Higher Education Coordinating Board
- Created
-
2018-09-28Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
- Series Name
- Proceedings of SPIE
- Series Volume or Issue Number
- 4960