An Open Resource for Non-human Primate Imaging

Creators: Milham, Michael P.; Tsao, Doris Y.

Abstract

Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design, and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 25 independent data collections aggregated across 22 sites (total = 217 non-human primates). We also outline the unique pitfalls and challenges that should be considered in the analysis of non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets.

Additional Information

© 2018 The Authors. Published by Elsevier Inc. Under a Creative Commons Attribution 4.0 International license. Open Access funded by Wellcome Trust. We thank Cameron Craddock for his creation and open sharing of the Preprocessed Connectome Project (PCP) Quality Assessment Project (QAP), which was used here (http://preprocessed-connectomes-project.org/quality-assessment-protocol/index.html). Primary support for the work by M.P.M. and the INDI team was provided by gifts from Joseph P. Healy to the Child Mind Institute as well as by the BRAIN Initiative (R01MH111439). M.P.M. is a Randolph Cowen and Phyllis Green Scholar. Primary support for the work by C.S. is provided by the BRAIN Initiative (R01MH111439) and the Sylvio O. Conte Center "Neurobiology and Dynamics of Active Sensing" (P50MH109429). Primary support for the work by D.S.M. is provided by the Max Planck Society. Primary support for the work by T.B. and J.S. is provided by Project PRIMAVOICE, Pascal Belin, and French Agence Nationale de la Recherche. Primary support for the work by R.R. and D.T. is provided by NIH grant R01 EY019702. Primary support for the work by A.C. is provided by the National Natural Science Foundation of China (No. 31371029 and No. 31571121) and the Innovation Program of Shanghai Municipal Education Commission (No. 14ZZ051, No. 20130076120021, No. 15JC1400104, and No. 16JC1400100). Primary support for the work by S.C.K. and Y.-d.Z. is provided by the following grants: Ministry of Education of PRC Humanities and Social Sciences Research Grant 16YJC190006; STCSM Shanghai Pujiang Program 16PJ1402800l; STCSM Natural Science Foundation of Shanghai16ZR1410200; and National Key Fundamental Research (973) Program of China Grant 2013CB329501. Primary support for the work by Z.W. is provided by the National Natural Science Foundation of China (81571300, 31771174). Primary support for the work by F.H.-B., M.M., and C.G. is provided by the French National Research Agency (ANR-14-CE13-0005-1 and ANR-15-CE37-0003) and the NEURODIS Foundation. Primary support for the work by the Icahn School of Medicine at Mount Sinai was provided by a Charles H. Revson Senior Fellowship in the Biomedical Sciences to P.L.C. Primary support for the work by M.G.B. and J.H.M. provided by NIAP01AG016765. Primary support for the work by K.M., D.A.R., and A.S. from McGill University is provided by a grant from the Brain Canada Foundation. Primary support for the work by the NIMH is provided by the Intramural Research Program of the NIMH (ZICMH00289). Primary support for the work by P.R.R. and P.C.K. is provided by grants from the Netherlands Organisation for Scientific Research (NWO) and the European Union. Primary support for the work by B. Jarraya and S.D. are provided by CEA, University Paris-Saclay, INSERM, Fondation de France, and ERC. Primary support for the work by Newcastle University provided by Wellcome Trust, Medical Research Council, European Research Council, NC3Rs, and BBSRC. Primary support for work by E.L.S. and D.A.F. is provided by R01MH107508. Primary support for the work by S.K. and M.P. is provided by NIMH1P50MH109429, NIMHR01MH064043, and NEIR01EY017699. Primary support for the work by C.M.S. and W.F. is supported by a Human Frontier Science Program Long-Term Fellowship; the NIH; an Irma T. Hirschl/Monique Weill-Caulier Trusts Award; a Pew Scholar Award in the Biomedical Sciences; a McKnight Scholars Award; a Human Frontier Science Program Research Grant; the New York Stem Cell Foundation; the National Eye Institute; the NIMH; the NSF Science and Technology Center for Brains, Minds, and Machines; and the National Science Foundation. Primary support for the work by E.P., C.R.E.W., and C.E. is provided by Agence National de la Recherche, Fondation Neurodis, the LabEx CORTEXANR-11-LABX-0042, Fondation de France, Human Frontier Science Program, and Fondation pour la Recherche Médicale. Primary support for the work by E.Y. and N.H. is provided by the following grants: R01-NS081118, R01-NS085188, P41-EB015894, P30-NS076408, and the University of Minnesota Udall Center P50NS098573. Primary support for the work by the University of Oxford is provided by the Medical Research Council UK, the Biotechnology and Biological Sciences Research Council UK, the Royal Society, and the Wellcome Trust. Primary support for the work by E.L.A.B., O.S.T., P.L., K.N.L., and S.M.R. was provided by the John Templeton Foundation, the Canada Foundation for Innovation, and the Anna-Greta och Holger Crafoords Stiftelse. Primary support for the work by S.E. and R.S.M. is provided by the Canadian Institutes of Health Research and Brain Canada. Primary support for the work by C.M.S. and W.F. is supported by a Human Frontier Science Program Long-Term Fellowship (LT001118/2012). Author Contributions: Conception and Experimental Design, D.S.M., M.P.M., and C.E.S.; Implementation and Logistics, L.A., D.S.M., M.P.M., C.E.S., B.K., and T.X.; Data Collection, M.P.M., C.A., F.B., M.G.B., S.B.H., T.B., A.C., P.L.C., C.G.D., S.E., D.A.F., L.F., W.F., S.F.-W., T.D.G., C.G., F.H.-B., N.H., B.H., B. Jarraya, B. Jung, P.C.K., S.D., S.K., S.C.K., D.A.L., R.B.M., R.S.M., A.M., M.M., K.M., J.H.M., J. Nacef, J. Nagy, M.O.R., C.I.P., M.P., C.P., E.P., R.R., P.R.R., D.A.R., M.F.S.R., B.E.R., S.M.R., E.L.A.B., O.S.T., P.L, K.N.L., J. Sallet, M.C.S., J. Seidlitz, J. Sein, C.M.S., A.S., E.L.S., L.U., A.T., D.T., Z.W., C.R.E.W., E.Y., F.Q.Y., W.Z., Y.-d.Z., D.S.M., and C.E.S.; Data Informatics, B.K. and L.A.; Data Analysis, L.A. and M.P.M.; Drafting of the Manuscript, M.P.M.; Critical Review and Editing of the Manuscript, all authors. The authors declare no competing interests.

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