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Published February 15, 2008 | Accepted Version
Journal Article Open

Genetic Strategy to Prevent Influenza Virus Infections in Animals

Abstract

The natural reservoirs of influenza viruses are aquatic birds. After adaptation, avian viruses can acquire the ability to infect humans and cause severe disease. Because domestic poultry serves as a key link between the natural reservoir of influenza viruses and epidemics and pandemics in human populations, an effective measure to control influenza would be to eliminate or reduce influenza virus infection in domestic poultry. The development and distribution of influenza-resistant poultry represents a proactive strategy for controlling the origin of influenza epidemics and pandemics in both poultry and human populations. Recent developments in RNA interference and transgenesis in birds should facilitate the development of influenza-resistant poultry.

Additional Information

© 2008 by the Infectious Diseases Society of America. Potential conflicts of interest: none reported. Financial support: National Institutes of Health (grants AI56267, CA119349, and CA112967). Supplement sponsorship is detailed in the Acknowledgments. We thank Herman N. Eisen for his discussion and critical reading of the manuscript. The Harvard University Asian Flus and Avian Influenza Workshop was hosted by the Harvard University Department of Anthropology, Harvard School of Public Health, and Harvard Asia Center and was supported by the National Science Foundation, Harvard Asia Center, and the Michael Crichton Fund. Supplement sponsorship. This article was published as part of a supplement entitled "Avian and Pandemic Influenza: A Biosocial Approach," sponsored by the National Science Foundation, Harvard Asia Center, and the Michael Crichton Fund.

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August 19, 2023
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October 18, 2023