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Published March 11, 2008 | Published
Book Section - Chapter Open

Imaging of optical scattering contrast using ultrasound-modulated optical tomography

Abstract

Using a CCD-based speckle contrast detection scheme of ultrasound-modulated optical tomography (UOT), we show the feasibility of imaging objects having different optical scattering coefficients relative to the surrounding scattering medium. Our results show that the spatial resolution depends on the ultrasound parameters and the image contrast depends on the difference in scattering coefficient between the object and the surrounding medium. Experimental measurements are in agreement with Monte Carlo simulations and analytical calculations. This study complements previous UOT experiments that demonstrated optical absorption contrast. It also demonstrates that UOT complements photoacoustic tomography, which is sensitive to optical absorption contrast.

Additional Information

© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by the National Institutes of Health grants CA094267 and CA106728.

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