Published March 21, 2018
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Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold
Abstract
We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to detect tumors and reveal detailed angiographic information about human breasts. SBH-PACT provides high spatial and temporal resolutions with a deep in vivo penetration depth of over 4 cm. A volumetric breast image can be acquired by scanning the breast within a single breath hold (~15 sec). We imaged a healthy female volunteer and seven breast cancer patients. SBH-PACT clearly identified all tumors by revealing higher blood vessel densities and lower compliance associated with the tumors.
Additional Information
© 2018 Society of Photo-Optical Instrumentation Engineers. The authors would like to thank Xi Li and Ruth Holdener for useful discussions and patient recruitment. We are grateful to James Linders for technical support. We also thank Prof. James Ballard and Amy Leong for close reading of the paper. This work was sponsored by the United States National Institutes of Health (NIH) grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), and R01 EB016963.Attached Files
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Additional details
- Eprint ID
- 89401
- Resolver ID
- CaltechAUTHORS:20180905-144425867
- DP1 EB016986
- NIH
- R01 CA186567
- NIH
- R01 EB016963
- NIH
- Created
-
2018-09-06Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
- Series Name
- Proceedings of SPIE
- Series Volume or Issue Number
- 10494