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Published August 1996 | public
Journal Article

Engineering new functions and altering existing functions

Abstract

Structural and mechanistic information, sequence comparisons, and site-directed mutagenesis data continue to provide a basis for the rational design of new protein functions and the alteration of existing functions. Random mutagenesis and 'directed evolution' approaches, however, are making significant headway in solving protein engineering problems, proving highly practical for tuning properties such as enzyme substrate specificity.

Additional Information

© 1996 Published by Elsevier Ltd.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023