Published July 27, 2018
| Supplemental Material + Published
Journal Article
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Short Enantioselective Formal Synthesis of (–)-Platencin
Abstract
A short enantioselective formal synthesis of the antibiotic natural product platencin is reported. Key steps in the synthesis include enantioselective decarboxylation alkylation, aldehyde/olefin radical cyclization, and regioselective aldol cyclization.
Additional Information
© 2018 Georg Thieme Verlag Stuttgart. Dedicated to Prof. Dr. Scott E. Denmark on the occasion of his 65th birthday. We thank the NIH-NIGMS (R01 GM080269), DAAD (postdoctoral fellowship to C.D.), Eli Lilly (predoctoral fellowship to J.T.M.), Amgen, Bristol-Myers Squibb, Merck Research Laboratories, Abbott Laboratories, Boehringer-Ingelheim, and Caltech for generous funding. We also thank the UIC Department of Chemistry (startup funds to J.T.M.) and the National Science Foundation (CAREER Award 1654490 to J.T.M.). We thank Dr. Michael W. Day and Larry Henling for crystallographic analysis.Attached Files
Published - s-0037-1610437.pdf
Supplemental Material - sup_ss-2018-c0304-op_10-1055_s-0037-1610437.pdf
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s-0037-1610437.pdf
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Additional details
- PMCID
- PMC6498846
- Eprint ID
- 88358
- DOI
- 10.1055/s-0037-1610437
- Resolver ID
- CaltechAUTHORS:20180730-120150815
- R01 GM080269
- NIH
- Deutscher Akademischer Austauschdienst (DAAD)
- Eli Lilly
- Amgen
- Bristol-Myers Squibb
- Merck Research Laboratories
- Abbott Laboratories
- Boehringer-Ingelheim
- Caltech
- University of Illinois, Chicago
- CHE-1654490
- NSF
- Created
-
2018-07-30Created from EPrint's datestamp field
- Updated
-
2022-02-17Created from EPrint's last_modified field