Published December 29, 1993
| Supplemental Material
Journal Article
Open
Assembly of DNA recognition elements on an octahedral rhodium intercalator: predictive recognition of 5'-TGCA-3' by Δ-[Rh[(R,R)-Me_2trien]phi]^(3+)
Abstract
Here we explore the de novo design of rhodium intercalators for predictive four base pair recognition of duplex DNA. Complexes have been constructed which, like DNA-binding proteins, pose several functionalities for site-specific noncovalent interaction with DNA. Octahedral rhodium intercalators are particularly useful in this design since (i) the octahedral coordination specifies the stereochemistry of ligand functionalities and (ii) the intercalating ligands orients these functionalities with respect to the DNA major groove.
Additional Information
© 1993 American Chemical Society. Received August 9, 1993. We are grateful to the National Institutes of Health (GM33309) for their financial support. In addition we thank the Deutsche Forschungsgemeinschaft (A.H.K.) for postdoctoral and the National Science Foundation (B.P.H.) for predoctoral fellowships.Attached Files
Supplemental Material - ja00079a044_si_001.pdf
Supplemental Material - ja12577.pdf
Files
ja00079a044_si_001.pdf
Files
(688.3 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:b1f3198763305731b4970c8a94ebd560
|
640.9 kB | Preview Download |
|
md5:437494609c3dda0b0699b5e5844c7d3f
|
47.4 kB | Preview Download |
Additional details
- Alternative title
- Assembly of DNA recognition elements on an octahedral rhodium intercalator: predictive recognition of 5'-TGCA-3' by .DELTA.-[Rh[(R,R)-Me2trien]phi]3+
- Eprint ID
- 86678
- DOI
- 10.1021/ja00079a044
- Resolver ID
- CaltechAUTHORS:20180529-143627642
- GM33309
- NIH
- Deutsche Forschungsgemeinschaft (DFG)
- NSF Predoctoral Fellowship
- Created
-
2018-05-29Created from EPrint's datestamp field
- Updated
-
2021-11-15Created from EPrint's last_modified field