Published January 1, 1997
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Journal Article
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Structural Studies of Λ- and Δ-[Ru(phen)_2dppz]^(2+)Bound to d(GTCGAC)_2: Characterization of Enantioselective Intercalation
Abstract
^1H and ^(31)P NMR have been applied in characterizing the enantioselective interactions between Λ- and Δ-[Ru(phen)_2dppz]^(2+) and the hexamer oligonucleotide d(GTCGAC)_2. Both isomers intercalate into the helix, and intermolecular NOEs place the Δ-isomer in the major groove. The NMR results indicate that Ru(phen)_2dppz^(2+) isomers bind to the DNA helix with a population of intercalative geometries and therefore extend earlier structural models based upon luminescence studies.
Additional Information
© 1997 American Chemical Society. Received June 20, 1996. Publication Date (Web): January 1, 1997. We are grateful to the NIH (Grant GM33309) for their financial support of this work. In addition C.M.D. thanks the NSF for a postdoctoral fellowship.Attached Files
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Additional details
- Eprint ID
- 86410
- DOI
- 10.1021/ic960738a
- Resolver ID
- CaltechAUTHORS:20180515-132544141
- GM33309
- NIH
- NSF Postdoctoral Fellowship
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2018-05-18Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field