Published December 4, 1998
| public
Journal Article
Mechanistic Insights into Cu-Catalyzed Asymmetric Aldol Reactions: Chemical and Spectroscopic Evidence for a Metalloenolate Intermediate
Abstract
In situ IR spectroscopy and transmetalation experiments confirm a postulated catalytic cycle. The metalloenolate 1 describes the active intermediate in the aldol reaction catalyzed by [CuF_2{(S)‐tol‐binap}] (see reaction scheme). (S)‐tol‐binap=(S)‐(−)‐2,2′‐bis(di‐p‐tolylphosphanyl)‐1,1′‐binaphthyl.
Additional Information
© 1998 Wiley‐VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany. Issue Online 17 December 1998; Version of Record online: 17 December 1998; Manuscript received: 16 June 1998. B.L.P. thanks the National Institutes of Health (NIH), J.K. thanks the Deutsche Forschungsgemeinschaft, and A.S. is grateful to the Schweizerischer Nationalfonds for postdoctoral fellowships. Financial support was provided by the Packard Foundation, National Science Foundation (USA), NIH (USA), and generous funds from Eli Lilly, Merck, Novartis, Pfizer, Upjohn, and Zeneca.Additional details
- Eprint ID
- 86248
- DOI
- 10.1002/(SICI)1521-3773(19981204)37:22<3124::AID-ANIE3124>3.0.CO;2-1
- Resolver ID
- CaltechAUTHORS:20180507-135626223
- NIH
- Deutsche Forschungsgemeinschaft (DFG)
- Schweizerischer Nationalfonds
- David and Lucile Packard Foundation
- NSF
- Eli Lilly
- Merck
- Novartis
- Pfizer
- Upjohn
- Zeneca
- Created
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2018-05-07Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field