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Published March 2018 | public
Conference Paper

Living with oxos

Gray, Harry ORCID icon

Abstract

The theory of multiple bonding in metal oxos, which accounts for their ground state electronic structures and spectroscopic properties, predicts that an "oxo wall" separates Fe-Ru-Os and Co-Rh-Ir in the periodic table. After reviewing this work, I will discuss the roles metal oxos play in hydrocarbon oxygenation catalyzed by cytochrome P 450. Interestingly, Jay Winkler and I have found that most P450s have Trp/Tyr chains very near the heme active sites. We have suggested that uncoupled high-valent iron-oxo intermediates would be reduced by hole transfer to these chains, thereby protecting P450s from oxidative degrdn.

Additional Information

© 2018 American Chemical Society.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023