On demonstrating DNA intercalation
- Creators
- Long, Eric C.
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Barton, Jacqueline K.
Abstract
Considerable attention has focused on new DNA-binding and -modifying agents, from natural products to wholly synthetic designs, as probes of DNA structure and as potential chemotherapeutic agents. The application of these molecules necessitates a precise understanding of the structural details of the agents' mode of interaction with the target molecule, double-helical DNA. DNA binding agents tend to interact noncovalently with the host molecule through two general modes: (i) in a groove-bound fashion stabilized by a mixture of hydrophobic, electrostatic, and hydrogen-bonding interactions and (ii) through an intercalative association in which a planar, heteroaromatic moiety slides between the DNA base pairs. Surprisingly, however, only a fraction of known DNA-interactive agents have been structurally characterized to atomic detail in noncovalent complexes with DNA.
Additional Information
© 1990 by the American Chemical Society. Registered in U.S. Patent and Trademark Office. We are grateful to the National Institutes of Health for their support of our work. E.C.L. is a Fellow of the Jane Coffin Childs Memorial Fund for Medical Research.Additional details
- Eprint ID
- 83056
- DOI
- 10.1021/ar00177a001
- Resolver ID
- CaltechAUTHORS:20171108-084900678
- NIH
- Jane Coffin Childs Memorial Fund for Medical Research
- Created
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2017-11-08Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field