Directed Evolution: Bringing New Chemistry to Life

Creators: Arnold, Frances H.

Abstract

Tailor-made: Discussed herein is the ability to adapt biology's mechanisms for innovation and optimization to solving problems in chemistry and engineering. The evolution of nature's enzymes can lead to the discovery of new reactivity, transformations not known in biology, and reactivity inaccessible by small-molecule catalysts.

Additional Information

© 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited, and is not used for commercial purposes. Version of record online: 28 November 2017; Accepted manuscript online: 24 October 2017; Manuscript Received: 15 August 2017. I thank Sabine Brinkmann-Chen, Kai Chen, Stephan Hammer, Kari Hernandez, Xiongyi Huang, Jennifer Kan, Rusty Lewis, Chris Prier and Ruijie Zhang for the ideas, inspiration, data, and hard work that went into the examples presented here. I thank Kim Mayer for excellent editorial assistance. This work was supported by the National Science Foundation, Division of Molecular and Cellular Biosciences (grant MCB-1513007), the Resnick Sustainability Institute, and the Caltech CI2 innovation program. The author declares no conflict of interest.

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