Published September 2017
| Published
Journal Article
Open
Nicotine in the Endoplasmic Reticulum
Abstract
Nicotine activates plasma membrane (PM) nicotinic receptors (nAChRs), but also permeates into the endoplasmic reticulum (ER) and cis-Golgi, and there binds to nascent nAChRs. Other psychiatric and abused drugs may also enter the ER and bind their classical targets. Further progress requires direct proof, quantification, and time resolution of these processes in live cells and in the brain of animals. Therefore, we are developing genetically encoded fluorescent biosensors to study the subcellular pharmacokinetics of neural drugs.
Additional Information
© 2017 The Rockefeller University Press. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Article under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode, or updates thereof. Published September 4, 2017. Support: NIH, NARSAD, California TRDRP, and HHMI.Attached Files
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Additional details
- Eprint ID
- 81917
- Resolver ID
- CaltechAUTHORS:20170929-092012776
- NIH
- NARSAD
- California Tobacco-Related Disease Research Program
- Howard Hughes Medical Institute (HHMI)
- Created
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2017-09-29Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field