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Published April 2006 | Supplemental Material
Journal Article Open

Fast DNA Sequencing via Transverse Electronic Transport

Abstract

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual.

Additional Information

© 2006 American Chemical Society. Received 17 January 2006. Published online 11 March 2006. Published in print 1 April 2006. We gratefully acknowledge discussions with M. Ramsey and T. Schindler. This research is supported by the NIH-National Human Genome Research Institute (J.L. and M.D.) and by the National Science Foundation through its Graduate Fellowship program (M.Z.).

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August 19, 2023
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