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Published October 2017 | public
Journal Article

Design and Evolution of Enzymes for Non-natural Chemistry

Abstract

Enzymes are used in biocatalytic processes for the efficient and sustainable production of pharmaceuticals, fragrances, fine chemicals, and other products. Most bioprocesses exploit chemistry found in nature, but we are now entering a realm of biocatalysis that goes well beyond. Enzymes have been engineered to catalyze reactions previously only accessible with synthetic catalysts. Because they can be tuned by directed evolution, many of these new biocatalysts have been shown to perform abiological reactions with high activity and selectivity. We discuss recent examples, showcase catalyst improvements achieved using directed evolution, and comment on some current and future implications of non-natural enzyme evolution for sustainable chemical synthesis.

Additional Information

© 2017 Elsevier B.V. Received 27 April 2017, Revised 22 May 2017, Accepted 7 June 2017, Available online 10 June 2017.

Additional details

Created:
August 21, 2023
Modified:
October 26, 2023