Published June 14, 2017
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Palladium-catalyzed sequential monoarylation/amidation of C(sp^3)–H bonds: stereoselective synthesis of α-amino-β-lactams and anti-α,β-diamino acid
Abstract
Pd-Catalyzed sequential monoarylation/amidation of C(sp^3)–H bonds of alanine enabled by a removable 5-methoxyquinolin-8-amine (MQ) auxiliary is described. This process is highly efficient and compatible with a variety of functional groups, providing a general and practical access to various α-amino-β-lactams. The synthetic potential of this protocol is further demonstrated by the stereoselective synthesis of orthogonally protected anti-α,β-diamino acids.
Additional Information
© 2017 The Royal Society of Chemistry. Received 29th March 2017, Accepted 4th May 2017, First published on 12th May 2017. Financial support from the NSFC (21422206, 21572201), the National Basic Research Program of China (2015CB856600), and Zhejiang Provincial NSFC (LR17B020001) is gratefully acknowledged.Attached Files
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Additional details
- Eprint ID
- 77843
- Resolver ID
- CaltechAUTHORS:20170531-082654477
- 21422206
- National Natural Science Foundation of China
- 21572201
- National Natural Science Foundation of China
- 2015CB856600
- National Basic Research Program of China
- LR17B020001
- Zhejiang Provincial National Natural Science Foundation of China
- Created
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2017-05-31Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field