Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published June 2, 2004 | Supplemental Material
Journal Article Open

Dynamic Devices. Shape Switching and Substrate Binding in Ion-Controlled Nanomechanical Molecular Tweezers

Abstract

As examples of supramolecular devices performing chemical (ionic, molecular) control of binding events and models of related natural systems, two molecular conformational switches are described, which display cation-controlled nanomechanical motion coupled to substrate binding and release. The substrate binding relies on donor/acceptor interactions, provided by intercalation between planar sites located at the extremities of the switching units, whereas cation complexation is responsible for conformational regulation. The terpyridine py-py-py-based receptor is activated toward substrate binding upon complexation of a zinc(II) cation and operates in a two-state process. The replacement of the central pyridine by a 4,6-disubstituted pyridimine as in py-pym-py induces a state reversal and yields a new receptor which binds a substrate in the absence of cation, and releases it when copper(I) is introduced, following a three-step process. These systems represent effector-triggered supramolecular switching devices leading toward multistate nanomechanical chemical systems. These two systems illustrate the use of simple conformational switches in the binding site and allosteric regulation of substrate affinity.

Additional Information

© 2004 American Chemical Society. Received 23 December 2003. Published online 5 May 2004. Published in print 1 June 2004. A.P. acknowledges the support of the French Ministère de l'Éducation et de la Recherche by a predoctoral fellowship and is indebted to Dr. T. Balaban for generously supplying the 2,3,6,7-tetrakis(dodecyloxy)anthracene (TDOA) used in this study. R.G.K. is grateful to the french government for a postdoctoral Chateaubriand fellowship.

Attached Files

Supplemental Material - ja031915rsi20031223_050912.cif

Supplemental Material - ja031915rsi20031223_050930.cif

Supplemental Material - ja031915rsi20031223_050945.cif

Supplemental Material - ja031915rsi20031223_051000.cif

Supplemental Material - ja031915rsi20031223_051017.cif

Supplemental Material - ja031915rsi20031223_051031.cif

Files

Files (141.7 kB)
Name Size Download all
md5:f538e3829075f48ee27c292703193348
30.3 kB Download
md5:d0f28834086d228418f633b0a8c281d9
20.3 kB Download
md5:da75ca83bc1222f959d9616317daf5f1
21.0 kB Download
md5:a5a1bb6d3734e04615375659b1776d9e
28.6 kB Download
md5:583ebc78994172491353943a7d6f6904
29.0 kB Download
md5:5125df3dc625f51bc898e8c9c395c120
12.5 kB Download

Additional details

Created:
August 19, 2023
Modified:
October 25, 2023