Replication at periodically changing multiplicity of infection promotes stable coexistence of competing viral populations
Abstract
RNA viruses are widely used to study evolution experimentally. Many standard protocols of virus propagation and competition are done at nominally low multiplicity of infection (m.o.i.), but lead during one passage to two or more rounds of infection, of which the later ones are at high m.o.i. Here, we develop a model of the competition between wild type (wt) and a mutant under a regime of alternating m.o.i. We assume that the mutant is deleterious when it infects cells on its own, but derives a selective advantage when rare and coinfecting with wt, because it can profit from superior protein products created by the wt. We find that, under these assumptions, replication at alternating low and high m.o.i. may lead to the stable coexistence of wt and mutant for a wide range of parameter settings. The predictions of our model are consistent with earlier observations of frequency-dependent selection in vesicular stomatitis virus and human immunodeficiency virus type 1. Our results suggest that frequency-dependent selection may be common in typical evolution experiments with viruses.
Additional Information
© 2004 The Society for the Study of Evolution. Received November 10, 2003. Accepted November 18, 2003. COW was supported by the National Science Foundation under contract DEB-9981397 to C. Adami. ISN was supported by National Institutes of Health grant AI45686.Attached Files
Submitted - 0402010v1.pdf
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Additional details
- Eprint ID
- 76234
- Resolver ID
- CaltechAUTHORS:20170408-164157361
- DEB-9981397
- NSF
- AI45686
- NIH
- Created
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2018-03-09Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field