Expansion of the Gene Ontology knowledgebase and resources

Creators: Carbon, S.; Chan, J.; Kishore, R.; Lee, R.; Muller, H.-M.; Raciti, D.; Van Auken, K.; Sternberg, P. W.; Gene Ontology Consortium

Abstract

The Gene Ontology (GO) is a comprehensive resource of computable knowledge regarding the functions of genes and gene products. As such, it is extensively used by the biomedical research community for the analysis of -omics and related data. Our continued focus is on improving the quality and utility of the GO resources, and we welcome and encourage input from researchers in all areas of biology. In this update, we summarize the current contents of the GO knowledgebase, and present several new features and improvements that have been made to the ontology, the annotations and the tools. Among the highlights are 1) developments that facilitate access to, and application of, the GO knowledgebase, and 2) extensions to the resource as well as increasing support for descriptions of causal models of biological systems and network biology. To learn more, visit http://geneontology.org/.

Additional Information

© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Received October 25, 2016; Editorial Decision October 26, 2016; Accepted November 16, 2016. We want to acknowledge the broad community of scientists who have contributed to the GO knowledgebase, as biocurators and software developers (see http://geneontology.org/page/acknowledgments-contributors), and as authors of published papers that provide the basis for GO annotations (see http://geneontology.org/page/acknowledgments-authors). FUNDING: National Institutes of Health/National Human Genome Research Institute [HG002273] awarded to the PI group formed by (alphabetically) Judith A. Blake, J. Michael Cherry, Suzanna E. Lewis, Paul W. Sternberg and Paul D. Thomas, as well as additional funding awarded to each participating institution. For more details please visit: http://geneontology.org/page/go-consortium-contributors-list. Funding for open access charge: National Institutes of Health/National Human Genome Research Institute [HG002273]. Conflict of interest statement. None declared.

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