Published June 9, 2005
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Heterogeneous Reductive Isomerization Reaction Using Catalytic Pd/C and H_2
Abstract
A highly selective catalytic reductive isomerization reaction is described. The extremely mild and neutral reaction conditions (10% Pd/C, H_2, and MeOH at 0 °C) tolerate a wide range of functional groups and generally result in excellent yields. Mechanistic studies suggest that this reaction does not proceed via a stepwise reduction/elimination sequence or a π-allylpalladium intermediate.
Additional Information
© 2005 American Chemical Society. Received 28 April 2005. Published online 14 May 2005. Published in print 1 June 2005. The authors gratefully acknowledge the NIH-NIGMS (R01 GM65961-01), the NDSEG (predoctoral fellowship to N.K.G.), Eli Lilly (predoctoral fellowship to D.D.C.), AstraZeneca, Boehringer Ingelheim, Johnson & Johnson, Pfizer, Merck, Amgen, Research Corporation, Roche, and GlaxoSmithKline for generous funding.Attached Files
Supplemental Material - ol050952fsi20050503_035630.pdf
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ol050952fsi20050503_035630.pdf
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Additional details
- Eprint ID
- 74474
- Resolver ID
- CaltechAUTHORS:20170222-150113004
- R01GM65961-01
- NIH
- National Defense Science and Engineering Graduate (NDSEG) Fellowship
- Eli Lilly
- AstraZeneca
- Boehringer-Ingelheim
- Johnson and Johnson
- Pfizer
- Merck
- Amgen
- Research Corporation
- Roche
- GlaxoSmithKline
- Created
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2017-02-23Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field