Published August 2004
| public
Journal Article
Origins of lymphocyte developmental programs: transcription factor evidence
- Creators
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Rothenberg, Ellen V.
- Pant, Rashmi
Abstract
This review explores the evolutionary origins of lymphocyte development by focusing on the transcription factors that direct mammalian lymphocyte development today. Gene expression data suggest that the programs to make lymphocytes involve the same transcription factor ensembles in all animals with lymphocytes. Most of these factors, GATA, Runx, PU.1/Spi, EBF/Olf, Ikaros, and Pax-2/5/8 family members, are also encoded in the genomes of animals without lymphocytes. We consider the functions of these factors in animals without lymphocytes in terms of discrete program components, which could have been assembled in a new way to create the lymphocyte developmental program ∼500 My ago.
Additional Information
© 2004 Elsevier Ltd. Available online 6 October 2004. The authors are very grateful to Michele K. Anderson for her invaluable expertise, critical reading of the manuscript, and thoughtful discussions of this field throughout several years of collaboration with us, during which many of the ideas presented here were first developed. We also thank Marianne Bronner-Fraser, Eric H. Davidson, Max D. Cooper, Gary W. Litman, Daniel Rokhsar, Jonathan Rast, David McCauley, and Zeev Pancer for stimulating discussions and insights and for kindly sharing results before publication, and we thank Rochelle A. Diamond for expert management of the Rothenberg laboratory. This work was supported by grants from NASA, NAG2-1370, and NAG2-1588.Additional details
- Eprint ID
- 74171
- Resolver ID
- CaltechAUTHORS:20170208-151304962
- NAG2-1370
- NASA
- NAG2-1588
- NASA
- Created
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2017-02-08Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field