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Published February 2013 | public
Book Section - Chapter

An integrated magnetic spectrometer for multiplexed biosensing

Abstract

There is high demand for at-home and point-of-care medical diagnostic tools as a step toward fast, low-cost, personal medicine. Integrated biosensors based on magnetic labeling schemes offer higher sensitivity and lower cost due to the elimination of the optics and have emerged as a viable alternative to assays that use fluorescence for biomolecular detection. For instance, the frequency-shift sensor of [1] demonstrates a high-sensitivity example of a cost-effective magnetic particle biosensor in CMOS with no need for external magnets. Despite their cost and sensitivity advantages, magnetic biosensors reported so far suffer from a lack of multi-probe diagnostics similar to fluorescent-based approaches that use multiple colors for simultaneous single-site multiple target differentiation. This is primarily because current approaches measure changes in the magnetic susceptibility, χ, either at low frequencies [2,3] or at a fixed RF frequency [1]. Consequently, these approaches do not provide a clear path for differentiating between a large number of small magnetic particles vs. a smaller number of larger size particles with similar magnetic content.

Additional Information

© 2013 IEEE. The authors thank the members of Caltech CHIC and MICS group for technical discussions, Yun E. Wang for assistance in sample preparation, and ST Microelectronics for chip fabrication. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1144469.

Additional details

Created:
August 19, 2023
Modified:
October 24, 2023