Barium titanate nanoparticles used as second harmonic radiation imaging probes for cell imaging
Abstract
Luminescent markers play a key role in imaging techniques for life science since they provide a contrast mechanism between signal and background. We describe a new type of marker using second harmonic generation (SHG) from noncentrosymmetric BaTiO_3 nanocrystals. These nanoparticles are attractive due to their stable, non-saturating and coherent signal with a femtosecond-scale response time and broad flexibility in the choice of excitation wavelength. In this paper, we report the use of nanoparticles for cell imaging. We first stabilized the BaTiO_3 nanoparticles in suspension and characterized the optical properties. We also demonstrated the functionalization of BaTiO_3 nanoparticles by conjugating IgG antibody on the surface of the nanoparticles. These functionalized nanocrystals are capable of specific labeling the antigens of interest.
Additional Information
© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE).Attached Files
Published - 73670D_1.pdf
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Additional details
- Eprint ID
- 73662
- Resolver ID
- CaltechAUTHORS:20170124-102704755
- Created
-
2017-01-26Created from EPrint's datestamp field
- Updated
-
2021-11-11Created from EPrint's last_modified field
- Series Name
- Proceedings of SPIE
- Series Volume or Issue Number
- 7367