Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published December 14, 2016 | Supplemental Material
Journal Article Open

Diastereoselective access to substituted 4-aminopiperidines via a pyridine reduction approach

Abstract

We describe herein a diastereoselective approach to access substituted-4-aminopiperidines from pyridine precursors. This methodology has successfully been applied to synthesize 2-alkyl substrates as well as more complex molecular entities of interest to the pharmaceutical industry.

Additional Information

© 2016 Elsevier. Received 11 October 2016; revised 21 October 2016; accepted 27 October 2016; available online 2 November 2016. The authors would like to thank Jason Ewanicki and Wei Wang for stereochemical analysis of 2, 5, 15, and 18; Phuong Tran for purification of 5 via liquid chromatography; and Loanne Chung for separation of cis/trans diastereomers of 2 via liquid chromatography. Additionally, the authors would like to thank Ted W. Johnson and Robert Kania for help in preparing this manuscript.

Attached Files

Supplemental Material - mmc1.docx

Supplemental Material - mol.zip

Files

mol.zip
Files (163.8 kB)
Name Size Download all
md5:935d43b63ce27c5eb029d288c5a9415b
12.5 kB Preview Download
md5:3a3670c596563bc1e469daf17de419a7
151.3 kB Download

Additional details

Created:
August 22, 2023
Modified:
October 24, 2023