Published December 14, 2016
| Supplemental Material
Journal Article
Open
Diastereoselective access to substituted 4-aminopiperidines via a pyridine reduction approach
Abstract
We describe herein a diastereoselective approach to access substituted-4-aminopiperidines from pyridine precursors. This methodology has successfully been applied to synthesize 2-alkyl substrates as well as more complex molecular entities of interest to the pharmaceutical industry.
Additional Information
© 2016 Elsevier. Received 11 October 2016; revised 21 October 2016; accepted 27 October 2016; available online 2 November 2016. The authors would like to thank Jason Ewanicki and Wei Wang for stereochemical analysis of 2, 5, 15, and 18; Phuong Tran for purification of 5 via liquid chromatography; and Loanne Chung for separation of cis/trans diastereomers of 2 via liquid chromatography. Additionally, the authors would like to thank Ted W. Johnson and Robert Kania for help in preparing this manuscript.Attached Files
Supplemental Material - mmc1.docx
Supplemental Material - mol.zip
Files
mol.zip
Additional details
- Eprint ID
- 73185
- DOI
- 10.1016/j.tetlet.2016.10.107
- Resolver ID
- CaltechAUTHORS:20170103-150357846
- Created
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2017-01-04Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field