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Published November 7, 2016 | public
Journal Article

Signaling Boundary Conditions Drive Self-Organization of Human "Gastruloids"

Abstract

Morphogenesis requires tissues to sense and respond to their geometry. In this issue of Developmental Cell, Etoc et al. (2016) show that a confined colony of human embryonic stem cells can spontaneously sense its boundary, generating a self-organized TGF-β signaling gradient that patterns it into a tissue resembling a gastrulating embryo.

Additional Information

© 2016 Elsevier Inc. Available online 7 November 2016.

Additional details

Created:
August 18, 2023
Modified:
March 5, 2024