Published December 1975
| public
Journal Article
The Organization, Expression, and Evolution of Antibody Genes and Other Multigene Families
- Creators
-
Hood, L.
- Campbell, J. H.
- Elgin, S. C. R.
Abstract
Antibodies represent a complex eukaryotic system that has fascinated biologists for the past 75 years. The immune system has evolved novel and sophisticated strategies for dealing with extremely large amounts of information. These include strategies for information storage, information expression, and information evolution. Indeed, one of the driving forces in molecular immunology has been the attempt to formulate and analyze mechanisms responsible for the diversity of antibodies. Perhaps this consideration, more than any other, convinced many biologists that the immune system has evolved unique genetic strategies to protect the integrity of the vertebrate organism. We disagree with this viewpoint.
Additional Information
© 1975 Annual Reviews. We thank Dr. John Smart for his participation in the early formative stages of this review. We also thank Drs. S. Rudikoff and E. Appella for the use of their unpublished sequences. The Caltech secretaries, as always, were superb. This work was supported by grants from the National Science Foundation, the National Institutes of Health, and the California Institute for Cancer Research. LH is the recipient of an NIH Research Career Development Award.Additional details
- Eprint ID
- 71280
- DOI
- 10.1146/annurev.ge.09.120175.001513
- Resolver ID
- CaltechAUTHORS:20161019-131227879
- NSF
- NIH
- California Institute for Cancer Research
- Created
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2016-10-19Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field