In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth

Creators: Yao, Junjie; Maslov, Konstantin I.; Shi, Yunfei; Taber, Larry A.; Wang, Lihong V.

Abstract

A method is proposed to measure transverse blood flow by using photoacoustic Doppler broadening of bandwidth. By measuring bovine blood flowing through a plastic tube, the linear dependence of the broadening on the flow speed was validated. The blood flow of the microvasculature in a mouse ear and a chicken embryo (stage 16) was also studied.

Additional Information

© 2010 Optical Society of America. Received January 4, 2010; revised March 14, 2010; accepted March 15, 2010; posted April 2, 2010 (Doc. ID 122113); published April 28, 2010. The authors thank Christopher Favazza, Song Hu, and Arie Krumholz for helpful discussion. This research was supported by the National Institutes of Health (NIH) grants R01 EB000712, R01 NS46214, R01 EB008085, R01 CA113453901, U54 CA136398, and 5P60 DK02057933. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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