Sequence organization in animal DNA and a speculation on hnRNA as a coordinate regulatory transcript
Abstract
The proposal is made that hnRNA is a coordinate regulatory transcript consisting principally of repetitive regulatory sequences and single-copy spacer sequences. The large transcription units characteristic of animal cells are interpreted as mechanisms for ensuring transcription of multiple regulatory signals under the control of single initiation sites. This organization of transcription is conceived to be a part of the system which integrates the control of gene expression. Animal DNA sequence organization is considered in this light and various consequences of these ideas are explored. Some testable predictions are developed for two cases: (a) that the regulatory signals are diffusible RNA activators originating from the short repetitive sequences interspersed in hnRNA and (b) that the regulatory signals are protein activators coded by message sequences embedded in the hnRNA transcript.
Additional Information
© 1977 Academic Press, Inc. Received 2 July 1976, Accepted 5 August 1976. We would like to thank a number of our colleagues for their careful reading of this manuscript and for their exceedingly useful critical reviews of it. We are particularly indebted in this respect to Professor Norman Davidson of this Institute, Professor David Hogness of Stanford University, and Professor Richard Axel of Columbia University. This work was supported by a grant from the National Institutes of Health, HD-05753.Additional details
- Eprint ID
- 69391
- Resolver ID
- CaltechAUTHORS:20160802-115919217
- HD-05753
- NIH
- Created
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2016-08-03Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field